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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   GSAP Blocking Peptide   

GSAP Blocking Peptide

Product Information
Primary Accession A4D1B5
Gene ID 54103
Calculated MW 97802 Da
Additional Information
Gene ID 54103
Application & Usage The peptide is used for blocking the antibody activity of GSAP antibody. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Gamma-secretase-activating protein, GSAP, Protein pigeon homolog, Gamma-secretase-activating protein 16 kDa C-terminal form, GSAP-16K, GSAP, PION
Target/Specificity GSAP
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsGSAP Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PION
Function Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
Cellular Location Golgi apparatus, trans-Golgi network
Tissue Location Widely expressed.
Research Areas
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$ 95.00
Cat# PBV10128b
(40 western blots)
Availability: 5-7days
Bulk Size
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