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Bcl-xL Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q64373 |
|---|---|
| Other Accession | L35049 |
| Gene ID | 561740 |
| Calculated MW | 26132 Da |
| Gene ID | 12048 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of Bcl-xL. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Target/Specificity | Bcl-xL |
| Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Bcl-xL Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Bcl2l1 |
|---|---|
| Synonyms | Bcl2l, Bclx |
| Function | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. |
| Cellular Location | Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome when phosphorylated at Ser-49 [Isoform Bcl-X(delta-TM)]: Cytoplasm. |
| Tissue Location | Widely expressed, with highest levels in the brain, thymus, bone marrow, and kidney. Bcl-X(L) and Bcl-X(delta-TM) expression is enhanced in B- and T-lymphocytes that have been activated. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# PBV10130b-50
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