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Bcl-xL Blocking Peptide

Product Information
Primary Accession Q64373
Other Accession L35049
Gene ID 561740
Calculated MW 26132 Da
Additional Information
Gene ID 12048
Application & Usage The peptide is used for blocking the antibody activity of Bcl-xL. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Target/Specificity Bcl-xL
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsBcl-xL Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bcl2l1
Synonyms Bcl2l, Bclx
Function Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Cellular Location Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome when phosphorylated at Ser-49 Isoform Bcl-X(delta-TM): Cytoplasm.
Tissue Location Widely expressed, with highest levels in the brain, thymus, bone marrow, and kidney. Bcl-X(L) and Bcl-X(delta- TM) expression is enhanced in B- and T-lymphocytes that have been activated.
Research Areas
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$ 95.00
Cat# PBV10130b
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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