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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CREB Blocking Peptide   

CREB Blocking Peptide

Product Information
Primary Accession P15337
Other Accession EDL98880
Gene ID 81646
Calculated MW 36633 Da
Additional Information
Gene ID 81646
Application & Usage Transcription factor CREB binds the cAMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth or neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinase CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Phosphorylation at Ser133 is also mediated by p44/42 MAP kinase, p90RSK, p38 MAP kinase and MSK1. CREB appears to play an important role in learning and memory in both flies and mice.
Other Names Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, Creb1, Creb-1
Target/Specificity CREB
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCREB Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Creb1
Synonyms Creb-1
Function Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity).
Cellular Location Nucleus.
Research Areas
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$ 95.00
Cat# PBV10148b
(40 western blots)
Availability: 5-7days
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