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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Stat2 Blocking Peptide   

Stat2 Blocking Peptide

     
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Product Information
Primary Accession P52630
Other Accession CAE45713.1
Gene ID 6773
Calculated MW 97916 Da
Additional Information
Gene ID 6773
Application & Usage The peptide is used for blocking the antibody activity of Stat2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Signal transducer and activator of transcription 2, p113, STAT2
Target/Specificity Stat2
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsStat2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAT2
Function Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).
Cellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta
Research Areas
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$ 95.00
Cat# PBV10197b-50
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