IL-1 RA, murine recombinant protein
IRAP, IL1F3, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, F630041P17Rik,
|Calculated MW||17.4 kDa|
|Other Names||IRAP, IL1F3, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, F630041P17Rik,|
|Sequence||The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Cys-Arg-Pro-Ser-Gly.|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in sterile ddH₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.|
|Storage||-20°C; Lyophilized from H₂O containing NaHCO₃|
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Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1 ra Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques.
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