|Calculated MW||16938 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of Fis1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||Mitochondrial fission 1 protein, FIS1 homolog, hFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, FIS1, TTC11|
|Formulation||50 µg (1 mg/ml) Fis1 peptide in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||Fis1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.|
|Cellular Location||Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein|
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