Granzyme A, human recombinant protein
CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor (H fact
|Calculated MW||26.9 kDa|
|Other Names||CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF|
|Source||Mammalian cell expression system|
|Sequence||Recombinant Human Granzyme A is produced with mammalian cells expression system. Target protein is expressed with sequence (Glu27-Val262) of Human granzyme a (Uniprot #P12544) fused with a polyhistidine tag at the C-terminus.|
|Application Notes||Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 µg/ml.). This can further be diluted to other aqueous buffers.|
|Storage||-20°C; Lyophilized from a 0.2 µm filtered solution of 20 mM MES and150 mM NaCl, pH 5.5.|
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Provided below are standard protocols that you may find useful for product applications.
Granzyme A is a member of the granzyme family. Granzyme A is the most abundant serine protease in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A has a specific function in CTL and NK cells. It induces caspase-independent cell death when introduced into target cells by perforin. Human granzyme A is synthesized as a precursor (262 residues) with a signal peptide (residues 1-26), a propeptide (residues 27-28) and a mature chain (residues 29-262).
Gershenfeld H.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:1184-1188(1988).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Schmutz J.,et al.Nature 431:268-274(2004).
Ruike Y.,et al.J. Hum. Genet. 52:172-178(2007).
Goralski T.J.,et al.Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
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