|Calculated MW||50433 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of beta-3 tubulin. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-III, TUBB3, TUBB4|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||Beta3-Tubulin (TUJ-1) Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues.|
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