RANTES, human recombinant protein
Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific prote
|Calculated MW||10.1 kDa|
|Other Names||Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine (C-C motif) ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.|
|Application Notes||Reconstitute in H₂O to a concentration of 0.1-1 µg/ µl. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°c for future use.|
|Storage||-20°C; Lyophilized with no additives|
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Provided below are standard protocols that you may find useful for product applications.
RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Schall T.J.,et al.J. Immunol. 141:1018-1025(1988).
Nomiyama H.,et al.J. Interferon Cytokine Res. 19:227-234(1999).
Capoulade-Metay C.,et al.Immunogenetics 58:533-541(2006).
Jang J.S.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Zeng Q.P.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
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