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ACAA2 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P13437 |
|---|---|
| Other Accession | EDL82881.1 |
| Gene ID | 170465 |
| Calculated MW | 41871 Da |
| Gene ID | 170465 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of ACAA2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Other Names | 3-ketoacyl-CoA thiolase, mitochondrial, 2.3.1.16, Acetyl-CoA acyltransferase, Beta-ketothiolase, Mitochondrial 3-oxoacyl-CoA thiolase, Acaa2 |
| Target/Specificity | ACAA2 |
| Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | ACAA2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Acaa2 |
|---|---|
| Function | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:16476568). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Expressed in liver, brown adipose tissue and heart (at protein level). |
Research Areas
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Application Protocols
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Discontinued
Cat# PBV10223b-50
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