TLR5 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9JLF7 |
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Other Accession | NP_058624 |
Gene ID | 53791 |
Calculated MW | 97627 Da |
Gene ID | 53791 |
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Application & Usage | The peptide is used for blocking antibody activity of TLR5. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
Other Names | Toll-like receptor 5, Tlr5 |
Target/Specificity | TLR5 |
Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | TLR5 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Tlr5 |
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Function | Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF- kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life. |
Cellular Location | Membrane; Single-pass type I membrane protein |
Tissue Location | Highly expressed in liver (PubMed:30089902). Detected in lung and at very low levels in most other tissues |
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