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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TRADD Blocking Peptide   

TRADD Blocking Peptide

Product Information
Primary Accession Q15628
Gene ID 8717
Calculated MW 34247 Da
Additional Information
Gene ID 8717
Application & Usage The peptide is used for blocking the antibody activity of active TRADD. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C
Other Names Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD
Target/Specificity TRADD
Formulation 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsTRADD Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus.
Tissue Location Found in all examined tissues.
Research Areas
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$ 95.00
Cat# PBV10233b
(40 western blots)
Availability: 5-7days
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