|Calculated MW||45265 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of Troy/TAJ. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||Tumor necrosis factor receptor superfamily member 19, TRADE, Toxicity and JNK inducer, Tnfrsf19, Taj, Troy|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||TROY/TAJ Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 4: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver|
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