Wnt-2 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P09544 |
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Gene ID | 7472 |
Calculated MW | 40418 Da |
Gene ID | 7472 |
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Application & Usage | The peptide is used for blocking the antibody activity of Wnt-2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
Other Names | Protein Wnt-2, Int-1-like protein 1, Int-1-related protein, IRP, WNT2, INT1L1, IRP |
Target/Specificity | Wnt-2 |
Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 1% BSA, 50% glycerol, and 0.02% thimerosal. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Wnt-2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WNT2 |
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Synonyms | INT1L1, IRP |
Function | Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as a upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). |
Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted |
Tissue Location | Expressed in brain in the thalamus, in fetal and adult lung and in placenta. |
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