|Calculated MW||102963 Da|
|Other Names||Megakaryocyte colony-stimulating factor, Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, ML, Megakaryocyte growth and development factor, MGDF, TPO, MKCSF, MPLLG, MGC163194, THPO.|
|Application Notes||Reconstitution in purified H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. For long term storage it is recommended to add a carrier protein (0.1% HAS or BSA).|
|Storage||-20°C; Lyophilized with no additives|
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Provided below are standard protocols that you may find useful for product applications.
TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.
Kimura S.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:5555-5559(1987).
Libert F.,et al.Nucleic Acids Res. 15:6735-6735(1987).
Kimura S.,et al.Biochemistry 28:4481-4489(1989).
Barnett P.S.,et al.Nucleic Acids Res. 18:670-670(1990).
Rapoport B.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
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