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>   home   >   Products   >   Proteins   >   PF 4, human platelets recombinant protein   

PF 4, human platelets recombinant protein

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Product info
Primary Accession P02776
Calculated MW 7.8 kDa
Additional Info
Gene ID 5196
Gene Symbol PLF4
Other Names CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.
Gene Source Human
Source Human platelets
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC; ≥95%
Recombinant No
Sequence The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu.
Target/Specificity PF 4
Application Notes Reconstitute in sterile ddH₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Format Lyophilized protein
Storage -20°C; Lyophilized from PBS buffer, pH 7.4.
Citations (0)

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Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.


Poncz M.,et al.Blood 69:219-223(1987).
Eisman R.,et al.Blood 76:336-344(1990).
Zhang C.,et al.Blood 98:610-617(2001).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 4,450.00
$ 190.00
Cat# PBV10246r
(40 western blots)
Availability: 5-7days
Bulk Size
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