PF 4, human platelets recombinant protein
CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.
|Calculated MW||7.8 kDa|
|Other Names||CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.|
|Sequence||The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu.|
|Application Notes||Reconstitute in sterile ddH₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.|
|Storage||-20°C; Lyophilized from PBS buffer, pH 7.4.|
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Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.
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Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
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