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Galectin-3 Blocking Peptide

     
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Product Information
Primary Accession P08699
Gene ID 83781
Additional Information
Application & Usage The peptide is used for blocking the antibody activity of Galectin-3. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C.
Other Names Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, IgE-binding protein, Laminin-binding protein, Lectin L-29, Mac-2 antigen, Lgals3
Target/Specificity Galectin-3
Formulation 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsGalectin-3 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lgals3
Function Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (By similarity). Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.
Cellular Location Cytoplasm. Nucleus. Secreted. Note=Secreted by a non- classical secretory pathway and associates with the cell surface EMBL; J02962; AAA40828.1; -; mRNA EMBL; BC089054; AAH89054.1; -; mRNA EMBL; M13697; AAA41378.1; -; mRNA PIR; A54889; A54889 RefSeq; NP_114020.1; NM_031832.1 UniGene; Rn.764; - ProteinModelPortal; P08699; - SMR; P08699; - STRING; 10116.ENSRNOP00000014216; - iPTMnet; P08699; - PhosphoSitePlus; P08699; - PaxDb; P08699; - PRIDE; P08699; - Ensembl; ENSRNOT00000014216; ENSRNOP00000014216; ENSRNOG00000010645 GeneID; 83781; - KEGG; rno:83781; - UCSC; RGD:69356; rat CTD; 3958; - RGD; 69356; Lgals3 eggNOG; KOG3587; Eukaryota eggNOG; ENOG4111EA0; LUCA GeneTree; ENSGT00760000119105; - HOGENOM; HOG000246423; - HOVERGEN; HBG006255; - InParanoid; P08699; - KO; K06831; - PhylomeDB; P08699; - TreeFam; TF315551; - Reactome; R-RNO-6798695; Neutrophil degranulation PRO; PR:P08699; - Proteomes; UP000002494; Chromosome 15 Bgee; ENSRNOG00000010645; - ExpressionAtlas; P08699; baseline and differential Genevisible; P08699; RN GO; GO:0009986; C:cell surface; IDA:RGD GO; GO:0005737; C:cytoplasm; IDA:RGD GO; GO:0005615; C:extracellular space; IDA:RGD GO; GO:0005634; C:nucleus; IDA:RGD GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW GO; GO:0050785; F:advanced glycation end-product receptor activity; IDA:RGD GO; GO:0048030; F:disaccharide binding; IDA:RGD GO; GO:0034988; F:Fc-gamma receptor I complex binding; IDA:RGD GO; GO:0019863; F:IgE binding; IDA:RGD GO; GO:0048029; F:monosaccharide binding; IDA:RGD GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD GO; GO:1903769; P:negative regulation of cell proliferation in bone marrow; IDA:RGD GO; GO:0045766; P:positive regulation of angiogenesis; IMP:RGD GO; GO:0008284; P:positive regulation of cell proliferation; IMP:RGD GO; GO:0014064; P:positive regulation of serotonin secretion; IDA:RGD GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW CDD; cd00070; GLECT; 1 InterPro; IPR013320; ConA-like_dom_sf InterPro; IPR015534; Galectin_3 InterPro; IPR001079; Galectin_CRD PANTHER; PTHR11346:SF26; PTHR11346:SF26; 1 Pfam; PF00337; Gal-bind_lectin; 1 SMART; SM00908; Gal-bind_lectin; 1 SMART; SM00276; GLECT; 1 SUPFAM; SSF49899; SSF49899; 1 PROSITE; PS51304; GALECTIN; 1 1: Evidence at protein level; Acetylation; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Disulfide bond; IgE-binding protein; Immunity; Innate immunity; Lectin; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Secreted; Spliceosome INIT_MET 1 1 Removed. CHAIN 2 262 Galectin-3 /FTId=PRO_0000076933 REPEAT 35 43 1 REPEAT 44 52 2 REPEAT 53 61 3 REPEAT 62 70 4 REPEAT 71 79 5 REPEAT 80 88 6 REPEAT 89 98 7; approximate REPEAT 99 105 8; approximate REPEAT 106 112 9; truncated DOMAIN 130 260 Galectin. {ECO:0000255|PROSITE- ProRule:PRU00639} REGION 35 112 9 X 9 AA tandem repeats of Y-P-G-X(3)-P- [GS]-[AG] REGION 193 199 Beta-galactoside binding. MOTIF 238 253 Nuclear export signal. MOD_RES 2 2 N-acetylalanine MOD_RES 6 6 Phosphoserine; by CK1 {ECO:0000250|UniProtKB:P38486} MOD_RES 200 200 Phosphoserine {ECO:0000250|UniProtKB:P17931} DISULFID 185 185 Interchain. CONFLICT 20 20 Q -> R (in Ref. 1; AAA40828) SEQUENCE 262 AA; 27202 MW; EADB994F5EBD493D CRC64; MADGFSLNDA LAGSGNPNPQ GWPGAWGNQP GAGGYPGASY PGAYPGQAPP GGYPGQAPPS AYPGPTGPSA YPGPTAPGAY PGPTAPGAFP GQPGGPGAYP SAPGAYPSAP GAYPATGPFG APTGPLTVPY DMPLPGGVMP RMLITIIGTV KPNANSITLN FKKGNDIAFH FNPRFNENNR RVIVCNTKQD NNWGREERQS AFPFESGKPF KIQVLVEADH FKVAVNDVHL LQYNHRMKNL REISQLGIIG DITLTSASHA MI
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$ 95.00
Cat# PBV10249b-50
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