|Calculated MW||16.0 kDa|
|Other Names||OB Protein, Obesity Protein, OBS, Obesity factor.|
|Application Notes||Add 15 mM sterile HCl (0.5 ml/1 mg vial or 5 ml/10 mg vial) to the vial. After the protein is completely dissolved, add 7.5 mM sterile NaOH (0.3 ml/1 mg vial or 3 ml/10 mg vial) to bring the pH to approximately 5.2.|
|Storage||-20°C; Sterile filtered and lyophilized|
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Provided below are standard protocols that you may find useful for product applications.
Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body’s fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Human Leptin is a 16 kDa protein containing 146 amino acid residues.
Zhang Y.,et al.Nature 372:425-432(1994).
Zhang Y.,et al.Nature 374:479-479(1995).
Masuzaki H.,et al.Diabetes 44:855-858(1995).
Gong D.W.,et al.J. Biol. Chem. 271:3971-3974(1996).
Chehab F.F.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
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