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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   HDAC-2 Blocking Peptide   

HDAC-2 Blocking Peptide

Product Information
Primary Accession Q92769
Other Accession EAW48255
Gene ID 3066
Calculated MW 55364 Da
Additional Information
Gene ID 3066
Application & Usage The peptide is used for blocking the antibody activity of active HDAC-2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C
Other Names Histone deacetylase 2, HD2,, HDAC2
Target/Specificity HDAC-2
Formulation 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsHDAC-2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC2
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Cellular Location Nucleus. Cytoplasm
Tissue Location Widely expressed; lower levels in brain and lung
Research Areas
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$ 95.00
Cat# PBV10256b
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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