HDAC-10 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q969S8 |
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Other Accession | AAL30513 |
Gene ID | 83933 |
Calculated MW | 71445 Da |
Gene ID | 83933 |
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Application & Usage | The peptide is used for blocking the antibody activity of HDAC-10. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
Other Names | Histone deacetylase 10, HD10, 3.5.1.98, HDAC10 |
Target/Specificity | HDAC-10 |
Formulation | 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | HDAC-10 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HDAC10 |
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Function | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome- lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). |
Cellular Location | Cytoplasm. Nucleus Note=Excluded from nucleoli. |
Tissue Location | Widely expressed with high levels in liver and kidney. |
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