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HDAC-10 Blocking Peptide

     
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Product Information
Primary Accession Q969S8
Other Accession AAL30513
Gene ID 83933
Calculated MW 71445 Da
Additional Information
Gene ID 83933
Application & Usage The peptide is used for blocking the antibody activity of HDAC-10. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Histone deacetylase 10, HD10, 3.5.1.98, HDAC10
Target/Specificity HDAC-10
Formulation 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsHDAC-10 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC10
Function Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome- lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039).
Cellular Location Cytoplasm. Nucleus Note=Excluded from nucleoli.
Tissue Location Widely expressed with high levels in liver and kidney.
Research Areas
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Discontinued
Cat# PBV10264b-50
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