BAFF Receptor, human recombinant protein
human BAFF Receptor, h-BAFF Receptor, rh-BAFF Receptor, recombinant human BAFF Receptor, recombinant
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96RJ3 |
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Calculated MW | 7.7 kDa |
Gene ID | 115650 |
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Gene Symbol | TR13C |
Other Names | Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, Short name=BAFF-R, BLyS receptor 3, CD_antigen=CD268 |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | HPLC; ≥95% |
Recombinant | Yes |
Results | 1-5 µg/ml |
Target/Specificity | BAFF Receptor |
Application Notes | Reconstitute in sterile H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4°C for 1 week or –20°C for future use. |
Format | Lyophilized protein |
Storage | -20°C; Sterile filtered and lyophilized from a solution (1 mg/ml) containing 20 mM phosphate buffer, pH 8.0, and 500 mM NaCl. |
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Provided below are standard protocols that you may find useful for product applications.
Background
BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFFR/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFFR is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extraCellular portion of the full BAFFR protein.
References
Thompson J.S.,et al.Science 293:2108-2111(2001).
Dunham I.,et al.Nature 402:489-495(1999).
Yan M.,et al.Curr. Biol. 11:1547-1552(2001).
Kayagaki N.,et al.Immunity 17:515-524(2002).
Gordon N.C.,et al.Biochemistry 42:5977-5983(2003).
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