|Calculated MW||83099 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of P-Selectin. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||P-selectin, CD62 antigen-like family member P, Granule membrane protein 140, GMP-140, Leukocyte-endothelial cell adhesion molecule 3, LECAM3, Platelet activation dependent granule-external membrane protein, PADGEM, CD62P, Selp, Grmp|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 0.5% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||P-Selectin Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface|
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