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LXR Blocking Peptide

Product Information
Primary Accession Q13133
Gene ID 10062
Calculated MW 50396 Da
Additional Information
Gene ID 10062
Application & Usage The peptide is used for blocking the antibody activity of active LXR. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37°C
Other Names Oxysterols receptor LXR-alpha, Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, NR1H3, LXRA
Target/Specificity LXR
Formulation 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsLXR Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR1H3
Synonyms LXRA
Function Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}
Tissue Location Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals
Research Areas
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$ 95.00
Cat# PBV10287b
(40 western blots)
Availability: 5-7days
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