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Beclin 1 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O88597 |
|---|---|
| Gene ID | 56208 |
| Calculated MW | 51589 Da |
| Gene ID | 56208 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of Beclin-1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Other Names | Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Becn1 |
| Target/Specificity | Beclin 1 |
| Formulation | 50 µg (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Beclin 1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Becn1 |
|---|---|
| Function | Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693, PubMed:28445460). Acts as a core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity). |
| Cellular Location | Cytoplasm. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endosome membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endosome Cytoplasmic vesicle, autophagosome. Note=Interaction with ATG14 promotes translocation to autophagosomes (By similarity) Expressed in dendrites and cell bodies of cerebellar Purkinje cells Localized to endosomes in neurons (PubMed:25275521) {ECO:0000250|UniProtKB:Q14457, ECO:0000269|PubMed:12372286, ECO:0000269|PubMed:25275521} [Beclin-1-C 37 kDa]: Mitochondrion |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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Discontinued
Cat# PBV10297b-50
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