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sRANK Ligand, murine recombinant protein
Soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE, TNF-related activation-induced cytokine,
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O35235 |
|---|---|
| Calculated MW | 19.4 kDa |
| Gene ID | 21943 |
|---|---|
| Gene Symbol | TNF11 |
| Other Names | Soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE, TNF-related activation-induced cytokine, OPGL, ODF, Osteoclast differentiation factor, Tumor necrosis factor ligand superfamily member 11, Receptor activator of nuclear factor kappa B ligand, RANKL, Osteoprotegerin ligand, CD254 antigen, sRANKL, sOdf. |
| Gene Source | Mouse |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | 5-10 ng/ml |
| Target/Specificity | sRANKL |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1-1.0 mg /ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized from 5 mM Tris, pH 7.6 + 75 mM NaCl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Murine RANK (receptor activator of NF-kB) is a newly discovered member of the TNFR family, identified as a dendritic cell membrane protein. The recombinant murine sRANK Ligand is a soluble 19.4 kDa protein, comprising the 174 amino acid residue TNF homologous region of RANKL.
References
Wong B.R.,et al.J. Biol. Chem. 272:25190-25194(1997).
Anderson D.M.,et al.Nature 390:175-179(1997).
Lacey D.L.,et al.Cell 93:165-176(1998).
Yasuda H.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:3597-3602(1998).
Kodaira K.,et al.Gene 230:121-127(1999).
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