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Leptin Receptor, human recombinant protein

OB Protein, Obesity Protein, OBS, Obesity factor

Product info
Primary Accession P41159
Calculated MW 95.0 kDa (predicted) 130-140 kDa on a gel.
Additional Info
Gene ID 3952
Gene Symbol LEP
Other Names OB Protein, Obesity Protein, OBS, Obesity factor, HuB219, OB receptor, CD_antigen=CD295
Gene Source Human
Source Human
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Sequence A DNA sequence encoding the extracellular domain (Met 1 - Asp 839) of human leptin receptor (NP_002294.2) was expressed and fused with a C-terminal polyhistidine tag. Predicted NT sequence is Phe 22.
Target/Specificity Leptin Receptor
Application Notes Centrifuge the vial prior to opening. The lyophilized Leptin Binding Domain is very soluble in H₂O and most aqueous buffers below and above the isoelectric point (~ 5.9).
Format Lyophilized protein
Storage -70°C; Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Citations (0)

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Leptin receptor (LEPR), also known as OB-R and B219, is a single transmembrane-domain receptor of the cytokine receptor family. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is expressed at high levels in hematopoietic stem cells, lymphohematopoietic cell lines, as well as adult reproductive organs. Several isoforms of LEPR have been identified, and LEPR structurally contains two hemopoietin receptor domains, a fibronectin type III domain and a WSXWS domain within the extracellular region. Interaction of leptin and leptin receptor is crucial for bodyweight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.


Zhang Y.,et al.Nature 372:425-432(1994).
Zhang Y.,et al.Nature 374:479-479(1995).
Masuzaki H.,et al.Diabetes 44:855-858(1995).
Gong D.W.,et al.J. Biol. Chem. 271:3971-3974(1996).
Chehab F.F.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.

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$ 190.00
$ 595.00
$ 4,950.00
Cat# PBV10321r
(40 western blots)
Availability: 5-7days
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