VEGF-B, human recombinant protein
Vascular Endothelial Growth Factor-B, VEGFB
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49765 |
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Calculated MW | 19.63 kDa |
Gene ID | 7423 |
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Gene Symbol | VEGFB |
Other Names | Vascular Endothelial Growth Factor-B, VEGFB, VEGF-related factor |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥98% |
Assay2&Purity2 | HPLC; |
Recombinant | Yes |
Results | 0.5-5.0 µg/ml. |
Target/Specificity | VEGF-B |
Application Notes | Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C. |
Format | Lyophilized protein |
Storage | -20°C; Lyophilized without additives |
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Provided below are standard protocols that you may find useful for product applications.
Background
VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, regulates angiogenesis and Vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.
References
Grimmond S.,et al.Genome Res. 6:124-131(1996).
Olofsson B.,et al.J. Biol. Chem. 271:19310-19317(1996).
Olofsson B.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:2576-2581(1996).
Iyer S.,et al.J. Mol. Biol. 359:76-85(2006).
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