Prohibitin Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P35232 |
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Gene ID | 5245 |
Calculated MW | 29804 Da |
Gene ID | 5245 |
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Application & Usage | The peptide is used for blocking the antibody activity of Prohibitin. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
Other Names | Prohibitin, PHB |
Target/Specificity | Prohibitin |
Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Prohibitin Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PHB1 {ECO:0000303|PubMed:28017329, ECO:0000312|HGNC:HGNC:8912} |
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Function | Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). |
Cellular Location | Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane |
Tissue Location | Widely expressed in different tissues. |
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