|Calculated MW||36866 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of GPVI. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||GPV1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass membrane protein|
|Tissue Location||Megakaryocytes and platelets.|
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