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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Lipocalin-2 Blocking Peptide   

Lipocalin-2 Blocking Peptide

Product Information
Primary Accession P11672
Gene ID 16819
Calculated MW 22875 Da
Additional Information
Gene ID 16819
Application & Usage The peptide is used for blocking the antibody activity of Lipocalin-2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Neutrophil gelatinase-associated lipocalin, NGAL, Lipocalin-2, SV-40-induced 24P3 protein, Siderocalin LCN2, p25, Lcn2
Target/Specificity Lipocalin-2
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsLipocalin-2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lcn2
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Cellular Location Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized
Tissue Location Detected in lung, spleen, uterus, vagina and epididymis.
Research Areas
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$ 95.00
Cat# PBV10369b
(40 western blots)
Availability: 5-7days
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