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Nectin-3/CD113 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NQS3 |
|---|---|
| Gene ID | 25945 |
| Calculated MW | 61002 Da |
| Gene ID | 25945 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of Nectin-3. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Other Names | Nectin-3, CDw113, Poliovirus receptor-related protein 3, CD113, PVRL3, PRR3 |
| Target/Specificity | Nectin-3/CD113 |
| Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Nectin-3/CD113 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NECTIN3 (HGNC:17664) |
|---|---|
| Synonyms | PRR3, PVRL3 |
| Function | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans- interaction with NECTIN2 at Sertoli-spermatid junctions. Trans- interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. |
| Cellular Location | Cell membrane; Single-pass membrane protein. Postsynaptic cell membrane |
| Tissue Location | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines |
Research Areas
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