|Calculated MW||28.8 kDa|
|Other Names||IBP-1, IGF-Binding Protein 1, AFBP, PP12, IGF-BP25, hIGFBP-1, IGFBP-1.|
|Application Notes||Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.|
|Storage||-20°C; Sterile filtered and lyophilized with no additives|
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Provided below are standard protocols that you may find useful for product applications.
Human IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, decidual, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, whereas nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a single, glycosylated protein consisting of 218 amino acid residues.
Brinkman A.,et al.EMBO J. 7:2417-2423(1988).
Brewer M.T.,et al.Biochem. Biophys. Res. Commun. 152:1289-1297(1988).
Grundmann U.,et al.Nucleic Acids Res. 16:8711-8711(1988).
Julkunen M.,et al.FEBS Lett. 236:295-302(1988).
Lee Y.-L.,et al.Mol. Endocrinol. 2:404-411(1988).
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