LASS5 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N5B7 |
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Other Accession | AAH33558.1 |
Gene ID | 91012 |
Calculated MW | 45752 Da |
Gene ID | 91012 |
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Application & Usage | The peptide is used for blocking the antibody activity of Lass5. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
Other Names | Ceramide synthase 5, CerS5, 2.3.1.24, LAG1 longevity assurance homolog 5, CERS5, LASS5 |
Target/Specificity | LASS5 |
Formulation | 50 µg (0.5 mg/ml) Lass5 peptide in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | LASS5 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CERS5 (HGNC:23749) |
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Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA)(PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D6K9}; Multi-pass membrane protein |
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