|Calculated MW||23130 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of NTAL. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||Linker for activation of T-cells family member 2, Linker for activation of B-cells, Non-T-cell activation linker, Lat2, Lab, Ntal, Wbscr5|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||NTAL/LAB Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Lab, Ntal, Wbscr5|
|Function||Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2 (By similarity).|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.|
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