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LDLR Blocking Peptide

Product Information
Primary Accession P01130
Gene ID 3949
Calculated MW 95376 Da
Additional Information
Gene ID 3949
Application & Usage The peptide is used for blocking the antibody activity of LDLR. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Low-density lipoprotein receptor, LDL receptor, LDLR
Target/Specificity LDLR
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsLDLR Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Cellular Location Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9
Research Areas
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$ 95.00
Cat# PBV10385b
(40 western blots)
Availability: 5-7days
Bulk Size
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