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Human CellExp Progranulin, Rat recombinant protein

Proepithelin; PEPI; PC Cell-derived Growth Factor

Product info
Primary Accession P23785
Concentration 0.3
Calculated MW ~65.0 kDa
Additional Info
Gene ID 10116
Gene Symbol GRN
Other Names Proepithelin; PEPI; PC Cell-derived Growth Factor
Gene Source Rat
Source HEK 293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Sequence Signal peptide and rat Progranulin (aa 1-602) fused at the C-terminus to a FLAG®-tag.
Application Notes Reconstitute in dH2O before use.
Format Lyophilized protein
Storage -20°C; Lyophilized from 0.2 µm-filtered solution in PBS.
Citations (0)

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Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. Rat Recombinant Progranulin fused to FLAG® at C-terminus produced in HEK is a single, glycosylated, polypeptide chain purified by standard chromatographic techniques, containing 602 amino acids and having a molecular mass of ~65.0 kDa.


Bhandari V.,et al.Endocrinology 133:2682-2689(1993).
Plowman G.D.,et al.J. Biol. Chem. 267:13073-13078(1992).
Shoyab M.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7912-7916(1990).
Bateman A.,et al.Biochem. Biophys. Res. Commun. 173:1161-1168(1990).

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$ 210.00
$ 730.00
Cat# PBV10387r
(40 western blots)
Availability: 5-7days
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