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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Insig1 Blocking Peptide   

Insig1 Blocking Peptide

Product Information
Primary Accession Q08755
Other Accession NP_071787
Gene ID 64194
Calculated MW 28232 Da
Additional Information
Gene ID 64194
Application & Usage The peptide is used for blocking the antibody activity of InSig-1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Insulin-induced gene 1 protein, INSIG-1, Immediate-early protein CL-6, Insulin-induced growth response protein CL-6, Insig1, Cl-6
Target/Specificity Insig1
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsInsig1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Insig1
Synonyms Cl-6
Function Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Highly expressed in liver and kidney.
Research Areas
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$ 95.00
Cat# PBV10397b
(40 western blots)
Availability: 5-7days
Bulk Size
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