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WNT-1, human recombinant protein


Product info
Primary Accession P04628
Calculated MW 38.4 kDa
Additional Info
Gene ID 7471
Gene Symbol WNT1
Other Names INT-1, Proto-oncogene Int-1 homolog
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 HPLC; ≥98%
Recombinant Yes
Results 1.5 - 2.5 ng/m
Application Notes Reconstitute in H₂O to a concentration of 0.1-1.0 µg/ µl. The solution can then be diluted into other aqueous buffers
Format Lyophilized protein
Storage -20°C; Sterile filtered and lyophilized with no additives
Citations (0)

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Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intraCellular signaling protein, β-catenine. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.


van Ooyen A.,et al.EMBO J. 4:2905-2909(1985).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Doubravska L.,et al.Cell. Signal. 23:837-848(2011).
Keupp K.,et al.Am. J. Hum. Genet. 92:565-574(2013).

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$ 195.00
$ 4,950.00
$ 595.00
Cat# PBV10397r
(40 western blots)
Availability: 5-7days
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