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Neuropilin-1 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P97333 |
|---|---|
| Other Accession | AAH60129 |
| Gene ID | 18186 |
| Calculated MW | 103000 Da |
| Gene ID | 18186 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of Neuropilin-1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Other Names | Neuropilin-1, A5 protein, CD304, Nrp1, Nrp |
| Target/Specificity | Neuropilin-1 |
| Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Neuropilin-1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Nrp1 {ECO:0000312|MGI:MGI:106206} |
|---|---|
| Synonyms | Nrp |
| Function | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed:26503042). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity). Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity). |
| Cellular Location | Mitochondrion membrane {ECO:0000250|UniProtKB:O14786}; Single-pass type I membrane protein. Cell membrane {ECO:0000250|UniProtKB:O14786}; Single- pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O14786} |
| Tissue Location | Nervous system. |
Research Areas
Citations (0)
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Application Protocols
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Discontinued
Cat# PBV10399b-50
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