|Calculated MW||54 kDa|
|Other Names||D4-GDI, D4GDI, Rho GDP dissociation inhibitor (GDI) α|
|Storage||-20°C; Sterile filtered liquid (100 µg/ml) in 50mM Tris-Acetate, pH 7.5, 1mM EDTA, 20% Glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
D4-GDI belongs to the family of rho-GDI or GDP-dissociation inhibitors for the Rho/Rac family of small G proteins; consisting of rhoGDI-1, D4-GDI/rhoGDI-2 and rhoGDI-3. It inhibits the release of GDP from the Rho proteins, essential for GTP-loading and activation of GTPase activity. D4-GDI is located in the cytoplasm and is involved in the regulation of the membrane association and dissociation cycle of Rho/Rac proteins. It is known to be a substrate for caspase 3 during Fas-mediated apoptosis.
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