p53, human recombinant protein
HGNC:11998, Cys51Stop, TRP53, p53
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P04637 |
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Calculated MW | 53.0 kDa |
Gene ID | 7157 |
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Gene Symbol | P53 |
Other Names | HGNC:11998, Cys51Stop, TRP53, p53 , Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | HPLC; ≥95% |
Recombinant | Yes |
Format | Liquid |
Storage | -20°C; 1 mg/ml in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, and 20% Glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. Recombinant human p53 protein purified by proprietary chromatographic techniques.
References
Zakut-Houri R.,et al.EMBO J. 4:1251-1255(1985).
Lamb P.,et al.Mol. Cell. Biol. 6:1379-1385(1986).
Harlow E.,et al.Mol. Cell. Biol. 5:1601-1610(1985).
Harris N.,et al.Mol. Cell. Biol. 6:4650-4656(1986).
Buchman V.L.,et al.Gene 70:245-252(1988).
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