|Calculated MW||81 kDa|
|Other Names||HGNC:11998, Cys51Stop, TRP53, p53 , Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53|
|Storage||-20°C; Sterile filtered (100 µg/ml) in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, and 20% Glycerol.|
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p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. Recombinant human mutant p53 protein is purified by proprietary chromatographic techniques.
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