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PTEN, human recombinant protein

Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Product info
Primary Accession P60484
Concentration 0.1
Calculated MW 80.0 kDa (GST tagged)
Additional Info
Gene ID 5728
Gene Symbol PTEN
Other Names Phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del,
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Format Liquid
Storage -80°C; 100 µg/ml in 50 mM Tris-Acetate, pH 7.5, 150 mM NaCl, 0.1 mM EDTA, 10 mM glutathione, 25 mM DTT, 0.1 mM PMSF and 25% Glycerol.
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PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques.

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$ 495.00
Cat# PBV10430r
(40 western blots)
Availability: 5-7days
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