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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   APG7/ATG7 Blocking Peptide   

APG7/ATG7 Blocking Peptide

Product Information
Primary Accession Q641Y5
Other Accession NP_001012097
Gene ID 312647
Calculated MW 77436 Da
Additional Information
Gene ID 312647
Application & Usage The peptide is used for blocking the antibody activity of Apg7/ATG7. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, APG7-like, Atg7, Apg7l
Target/Specificity APG7/ATG7
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAPG7/ATG7 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Atg7
Synonyms Apg7l
Function E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation (By similarity).
Cellular Location Cytoplasm. Preautophagosomal structure. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme
Tissue Location Widely expressed.
Research Areas
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$ 95.00
Cat# PBV10431b
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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