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APG12/ATG12 Blocking Peptide

     
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Product Information
Primary Accession Q9CQY1
Gene ID 67526
Calculated MW 15207 Da
Additional Information
Gene ID 67526
Application & Usage The peptide is used for blocking the antibody activity of Apg12/Atg12. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.
Other Names Ubiquitin-like protein ATG12, Autophagy-related protein 12, APG12-like, Atg12, Apg12, Apg12l
Target/Specificity APG12/ATG12
Formulation 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAPG12/ATG12 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Atg12
Synonyms Apg12, Apg12l
Function Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Cellular Location Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
Tissue Location Ubiquitous.
Research Areas
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$ 95.00
Cat# PBV10433b
Size:
Quantity:
(40 western blots)
Availability: 5-7days
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