|Calculated MW||74867 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of Pak6. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||Serine/threonine-protein kinase PAK 6, 188.8.131.52, p21-activated kinase 6, PAK-6, Pak6|
|Formulation||50 µg (0.5mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||PAK6 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.|
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