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PGC-1 alpha Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O70343 |
|---|---|
| Other Accession | NP_032930.1 |
| Gene ID | 19017 |
| Calculated MW | 90588 Da |
| Gene ID | 19017 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of PGC-1 alpha. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Other Names | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, Ppargc1a, Pgc1, Pgc1a, Ppargc1 |
| Target/Specificity | PGC-1 alpha |
| Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | PGC-1 alpha Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ppargc1a |
|---|---|
| Synonyms | Pgc1, Pgc1a, Ppargc1 |
| Function | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:12754525). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (By similarity). Also involved in the integration of the circadian rhythms and energy metabolism (PubMed:17476214). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (PubMed:17476214). |
| Cellular Location | Nucleus. Nucleus, PML body |
| Tissue Location | White quadriceps and red tibialis anterior (TA) muscles, liver, kidney and brown adipose tissue (at protein level) Skeletal muscle, brown adipose tissue, heart, kidney and brain |
Research Areas
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