ALK7 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8K348 |
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Gene ID | 269275 |
Calculated MW | 54700 Da |
Gene ID | 269275 |
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Application & Usage | The peptide is used for blocking the antibody activity of ALK7. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
Other Names | Activin receptor type-1C, 2.7.11.30, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, Acvr1c {ECO:0000312|EMBL:AAH28780.1} |
Target/Specificity | ALK7 |
Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | ALK7 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Acvr1c {ECO:0000312|EMBL:AAH28780.1} |
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Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
Cellular Location | Membrane; Single-pass type I membrane protein |
Tissue Location | Expressed in interdigital regions in developing limb buds. |
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