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AdipoR1 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q91VH1 |
|---|---|
| Other Accession | EDL39610 |
| Gene ID | 72674 |
| Calculated MW | 42366 Da |
| Gene ID | 72674 |
|---|---|
| Application & Usage | The peptide is used for blocking the antibody activity of AdipoR1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
| Other Names | Adiponectin receptor protein 1, Adipor1 |
| Target/Specificity | AdipoR1 |
| Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | AdipoR1 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Adipor1 {ECO:0000312|MGI:MGI:1919924} |
|---|---|
| Function | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17268472, PubMed:24742672). Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17327425, PubMed:17268472, PubMed:24742672). Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96A54} Note=Localized to the cell membrane and intracellular organelles {ECO:0000250|UniProtKB:Q96A54} |
| Tissue Location | Detected in brain and quadriceps muscle (at protein level) (PubMed:17327425). Widely expressed (PubMed:12802337). Expressed in heart, kidney, liver, lung, skeletal muscle, white adipose tissue, brown adipose tissue, aorta and spleen (PubMed:12802337, PubMed:24742672). Weakly expressed in brain and testis (PubMed:12802337). |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# PBV10452b-50
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