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Human CellExp LEFTY-I, Human recombinant protein

Human Recombinant LEFTY-I

     
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Product info
Primary Accession O75610
Calculated MW 38 kDa
Additional Info
Gene ID 10637
Gene Symbol LEFTY1
Other Names Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B
Gene Source Human
Source Human 293 cells
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Results Typically 10 to 40 ng/mL ED50.
Application Notes Reconstitute in sterile water.
Format Lyophilized protein
Storage -20°C; Lyophilized in 10 mM Tris-HCl, pH 7.4, 50 mM NaCl, 0.5% CHAPS.
Citations (0)

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Background

BioVision’s LEFTY-1 is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 38 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media. Lefty proteins function as an antagonist of the Nodal Signaling pathway. Proper functioning of Lefty is crucial to the proper development of the heart, lungs, spleen, and liver.

References

Kosaki K.,et al.Am. J. Hum. Genet. 64:712-721(1999).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 325.00
$ 1,250.00
Cat# PBV10458r-10
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