|Calculated MW||38 kDa|
|Other Names||Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B|
|Source||Human 293 cells|
|Results||Typically 10 to 40 ng/mL ED50.|
|Application Notes||Reconstitute in sterile water.|
|Storage||-20°C; Lyophilized in 10 mM Tris-HCl, pH 7.4, 50 mM NaCl, 0.5% CHAPS.|
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Provided below are standard protocols that you may find useful for product applications.
BioVision’s LEFTY-1 is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 38 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media. Lefty proteins function as an antagonist of the Nodal Signaling pathway. Proper functioning of Lefty is crucial to the proper development of the heart, lungs, spleen, and liver.
Kosaki K.,et al.Am. J. Hum. Genet. 64:712-721(1999).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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